Safety of Water Fluoridation

• Seven studies of osteosarcoma, presenting 12 analyses were included

• Of these, the direction of association between water fluoridation and osteosarcoma incidence or mortality was found to be:

• positive (fewer cancers) in seven,
• negative (more cancers) in three and
• no association (two found no relationship)

• Of the six studies that presented variance data

• Only one (Cohn 1992) found a statistically significant association between fluoridation and increased prevalence of osteosarcoma in males.
• This study however, also had the lowest validity score, 2.5 out of 8.

• Importance of not establishing or changing public policy based on a single study